Burkholderia cepacia is a complex species which have some different genomovars with various functions. All Burkholderia species possess very large genomes which underpins their versatility through time in diverse ecologically niche such as water, soil, chemical compounds. Even in human body. Although facilitate highly beneficial function like nitrogen fixation, sidrophore production and processes such as pollutants degrading, they are also capable of causing opportunistic infections in vulnerable individuals, especially people with cystic fibrosis (CF) and makes a serious threat. Therefore, it should not be advised as biological control without supplementary research.