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:: Volume 10, Issue 3 (11-2017) ::
2017, 10(3): 1-16 Back to browse issues page
Active immune induction by genetic vaccination
Malihe Naderi, Naghmeh Gholipour, Sakine Mashjoor
Department of Marine Biology, Hormozgan University
Abstract:   (778 Views)
DNA vaccination, or genetic immunization, is a novel vaccine technology that has great potential for reducing infectious disease and cancer- induced morbidity and mortality worldwide. This method has been used to stimulate protective immunity against many infectious pathogens, malignancies, and autoimmune disorders in animal models and extensively to develop vaccine safe, innovative and efficient in human and animals has been studied. DNA plasmids encoding foreign proteins may be used as immunogens by direct intramuscular injection alone, or with various adjuvants. The antibody, helper T lymphocyte, and cytotoxic T lymphocyte (CTL) responses have been induced in a laboratory and domesticated animals by these methods. In the inactive immunization method, the goal is only temporary protection and relief of the condition, but in active immunization, achieving a constant, long-term safety is the final goal. DNA vaccines are one of the novel candidates of genetic engineering in immunization fields. This article is aimed to introduce DNA vaccine and induced an immune response by it to achieve sustainable protection and further development of this technology at national research levels.
Keywords: DNA vaccination, Immune, Genetic immunization, Antibody.
Full-Text [PDF 937 kb]   (508 Downloads)    
Type of Study: Applicable | Subject: Special
Received: 2017/07/22 | Accepted: 2017/11/14 | Published: 2019/02/4
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Naderi M, Gholipour N, Mashjoor S. Active immune induction by genetic vaccination. Journal of Biosafety. 2017; 10 (3) :1-16
URL: http://journalofbiosafety.ir/article-1-192-en.html


Volume 10, Issue 3 (11-2017) Back to browse issues page
فصل نامه علمی-ترویجی ایمنی زیستی Journal of Biosafety
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