Use of pesticides, including pesticides during the past half century has been an alarming increase. Therefore, today Chemical control is performed in more than 99 percent of agricultural production in Iran. Accordingly, it will be very difficult to remove pesticides from agriculture. In addition to adverse effects of chemical pesticides on the health of agricultural producers and consumers, they have many irreparable effects on non-target organisms and biodiversity in general as well. Eliminate sensitive species on biodiversity can be dumped into the long term effects are irreparable. Pesticides are a major factor affecting biological diversity, along with habitat loss and climate change. They can have toxic effects in the short term in directly exposed organisms, or long-term effects by causing changes in habitat and the food chain. Due to the adverse effects of pesticides, the use of transgenic plants resistant to pests is a good choice to reduce the damage caused by insecticides.