In 2015, the area under cultivation of transgenic plants reached to more than 179/7 million ha. America, Argentina, Canada and China accounted for 99% of the cultivation of GM crops.  Meanwhile, cultivation of Bt crops, which are resistant to pesticides, are known to be on the rise. However, the effects of these plants on non-target organisms has raised concerns. After production of a transgenic crop, before the commercial release of the product, the safety of the product is evaluated and analyzed using food safety rules and standards. Based on past studies, the transgenic Bt plants do not have negative impact on the species of beneficial pollinator insects such as bees, larvae of green spider, predator insects such as ladybirds and other beneficial insects that eat aphids and tiny insects. Use of Bt transgenic crops reduces the use of insecticides, and as a result, this protects the health of the environment and agriculture. Development of Bt products can therefore be a useful component of management systems for protection against the pests. The purpose of this paper is to investigate the scientific aspects of evaluation of risk of Bt corps cultivation on non-target organisms.