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A Review of the Strategies to Attain the Maximum Productivity of Menaquinone Production from Bacillus subtilis
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Majid Azizi *   , Saeed Soheilivand |
| Assistant Professor, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran. |
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Abstract: (1056 Views) |
Increasing the productivity of processes as well as ease in up-scaling are prerequisites to enhancing the use of menaquinone-7 in various industries such as pharmaceutical and food. This review first focuses on the introduction, global trade, market value, and application of menaquinone-7. Then various strategies of industrial production are introduced along with related challenges. Next, the relative advantage of menaquinone-7 production from microbial sources, biosynthesis pathways, and key enzymes will be investigated. At the end, the strategies to enhance menaquinone-7 productivity such as mutagenesis and screening, metabolic pathway engineering, bioprocess engineering, and menaquinone-7 extraction from Bacillus subtilis will be introduced. |
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| Keywords: Vitamin K, Menaquinone, Bacillus subtilis, Productivity, Bioprocesses. |
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Full-Text [PDF 1414 kb]
(233 Downloads)
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Type of Study: Review |
Subject:
Special
Received: 2023/02/26 | Accepted: 2023/03/24 | Published: 2023/03/24
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