Consider to importance of food safety and the growing population, it is essential to increase agricultural production. However, plant pathogens and pests are hindering the achievement of this goal. On the other hand, due to the excessive use of chemical pesticides and their residual problems that reduce the health of the product and destroy its export value, researcher is looking for suitable alternatives. The use of biological compounds such as entomopathogenic bacteria can be used as a high-potential biological control agent in this field. Most entomopathogenic bacteria products are based on Bacillus thuringiensis, Saccharopolyspora spinosa, Bacillus megaterium, Bacillus popillia, Streptomyces avermitilis, Photorhabdus spp. and Xenorhabdus spp. Biological pesticides or their commercialized metabolites can be used in integrated management of most pests. These compounds are very harmless to human health, the environment and natural enemies. This review discusses the biological role of important entomopathogenic bacteria and mode of action on several important pest species.