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Investigation of interleukin-7 as a risk factor for incidence of Multiple sclerosis
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Maedeh Mohsenzadeh   , Noshad Peyravian , Mehrshid Farahi , Tahere Naji * |
| cell and molecular deparment,pharmaceutical sciences Branch,Islamic Azad university, Tehran,Iran. |
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Abstract: (3444 Views) |
| Multiple sclerosis (MS), is characterized as an inflammatory demyelinating disease that the insulating covers of nerve cells in the brain and spinal cord are damaged. Between genetic factors, differences in a group of genes on chromosome 6 that characterized as the major histocompatibility complex (MHC) have been repeatedly confirmed to be associated with multiple sclerosis. Cytokine IL-7 is a 25– kDaglycoprotein that has an important role in Lymphopoiesis. Interleukin VII receptor gene has been identified to be associated with multiple sclerosis, so its assessment is important Polymorphisms (single-nucleotide polymorphism (SNP)) in a number of non-HLA genes such as interleukin-7 receptor-α (IL-7Rα)/IL-7 pathway is associated with an increased risk to develop multiple sclerosis (MS). In this study we aimed to investgate the role of interleukin-7 receptor-α (IL-7Rα)/IL-7 as a risk factor for incidence of Multiple sclerosis. |
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| Keywords: Multiple sclerosis, single-nucleotide polymorphism, interleukin-7 receptor-α |
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Full-Text [PDF 625 kb]
(866 Downloads)
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Type of Study: Applicable |
Subject:
Special
Received: 2014/05/15 | Accepted: 2019/02/24 | Published: 2019/02/24
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