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Trichoderma Peptaibols: Structural Diversity, Bioactivities, and Novel Perspectives in Biotechnology
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Mahshid Abdoshahi   , Khadijeh Abbasi * |
| Assistant Professor, Department of Plant Protection, Faculty of Agriculture, Ilam University, Ilam, Iran |
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Abstract: (112 Views) |
Pepthaibols are a class of non-ribosomal peptides primarily produced by fungi of the genus Trichoderma. Their unique structure, which includes unusual amino acids such as α-aminoisobutyric acid (Aib), confers high rigidity and stability against enzymatic degradation. This characteristic allows pepthaibols to maintain broad biological activity even under harsh environmental conditions. Biologically, pepthaibols exhibit antifungal, antibacterial, antiviral, and antitumor activities, exerting their effects by forming channels in cell membranes and disrupting ionic balance. Furthermore, in plants, they induce systemic immune responses and enhance resistance to biotic and abiotic stresses. The biosynthesis of pepthaibols is carried out by large, multi-domain enzymes called non-ribosomal peptide synthetases (NRPS), with the relevant genes located in specific gene clusters within the Trichoderma fungal genome. The structural diversity, extensive biological activities, and potential for industrial production make pepthaibols an attractive option in biotechnology, sustainable agriculture, and pharmaceuticals.
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| Keywords: Biocontrol, Antimicrobial Peptides, Nanobiotechnology |
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Full-Text [PDF 1184 kb]
(142 Downloads)
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Type of Study: Review |
Subject:
Special
Received: 2025/10/3 | Accepted: 2026/01/27 | Published: 2026/05/20
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