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Novel Gene Delivery Systems Considering Biosafety
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Fatemeh Akbarian   , Amir Mousavi * , Mohammad Hossein Sanati , Naghmeh Gholipour , Simin Nafian Dehkordi1 , Farzaneh Khani |
| National Institute of Genetics and Biotechnology, Tehran, Iran. |
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Abstract: (4202 Views) |
| Gene therapy is a promising approach for the treatment of incurable diseases, including cancer and genetic defects. The major problem limiting the effectiveness of this method within the organism is the difficulty in transporting vulnerable and negatively charged DNA macromolecules into the cell nucleus, in which risks the biosafety aspects of gene therapy. The major key to successful gene therapy is developing safe and efficient tools for carrying the genetic material. Due to their high efficiency in transferring the genetic material, viral vectors are among the most commonly used vectors in gene therapy; however, they can spark dangerous immune responses in the body of the living organisms. Currently, researchers are trying to develop cheaper and safer alternatives. In this paper, the pathways and gene transfer techniques, along with their advantages and disadvantages are reviewed for the means of gene therapy. Furthermore, the latest reforms necessary for the improvement of each method are mentioned. |
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| Keywords: Gene therapy, biosafety, gene delivery systems, non- viral vectors, viral vectors. |
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Full-Text [PDF 869 kb]
(13424 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2014/08/4 | Accepted: 2017/10/14 | Published: 2019/02/16
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