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:: Volume 10, Issue 2 (8-2017) ::
2017, 10(2): 37-52 Back to browse issues page
In silico design of recombinant IFNα/β receptor protein to combat antagonistic effects of Ebola VP35 protein
Yaser Ghazi , Fatemeh Haddadi
M.Sc. Faculty of Sciences, Zabol of University, Iran
Abstract:   (290 Views)
The VP35 protein in Ebola virus is one of the main pathogenic components interacting to host cells and interferes with natural cellular immune responses. This is done by antagonistic potential of the viral VP35 protein which inhibits interferon regulatory factor 3 (IRF-3) protein in the infected cells and then induction of antiviral genes expression are disrupted. In the present in silico study, we have designed a novel recombinant IFNα/β receptor protein which can be secreted out by host cells and circulate in blood stream. When the body encounters the virus, the recombinant protein can binds to VP35 and inhibit its antagonistic effect on IRF-3 proteins. Evaluations made by bioinformatics softwares revealed that the novel recombinant protein show promise for ameliorating the virulence of Ebola. But the obtained results should be investigated in vitro and in vivo for further evaluation and possible approval as a therapeutic strategy.  
Keywords: antagonistic, bioinformatics, Ebola virus, IFNα/β receptor, VP35 protein
Full-Text [PDF 1101 kb]   (343 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/11/21 | Accepted: 2017/07/25 | Published: 2018/05/7
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ghazi Y, haddadi F. In silico design of recombinant IFNα/β receptor protein to combat antagonistic effects of Ebola VP35 protein. Journal of Biosafety. 2017; 10 (2) :37-52
URL: http://journalofbiosafety.ir/article-1-155-en.html


Volume 10, Issue 2 (8-2017) Back to browse issues page
فصل نامه علمی-ترویجی ایمنی زیستی Journal of Biosafety
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