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:: Volume 10, Issue 2 (8-2017) ::
2017, 10(2): 131-146 Back to browse issues page
Propolis and the immune system
Maghsoud Besharati , Mona Eftekhari
Animal Science, Faculty of Agriculture and Natural Resources, University of Tabriz, Tabriz, Iran
Abstract:   (940 Views)
Propolis has been used empirically for centuries and it was always mentioned as an immunomodulatory agent. In recent years, in vitro and in vivo assays provided new information concerning its mechanisms of action, thus a review dealing with propolis and the immune system became imperative. This review compiles data from our laboratory as well as from other researchers, focusing on its chemical composition and botanical sources, the seasonal effect on its composition and biological properties, its immunomodulatory and antitumor properties, considering its effects on antibody production and on different cells of the immune system, involving the innate and adaptive immune response. In vitro and in vivo assays demonstrated the modulatory action of propolis on murine peritoneal macrophages, increasing their microbicidal activity. Its stimulant action on the lytic activity of natural killer cells against tumor cells, and on antibody production was demonstrated. Propolis inhibitory effects on lymphoproliferation may be associated to its anti-inflammatory property. Since humans have used propolis for different purposes and propolis-containing products have been marketed, the knowledge of its properties with scientific basis is not only of academic interest but also of those who use propolis as well. This review opens a new perspective on the investigation of propolis biological properties, mainly with respect to the immune system.
Keywords: Propolis, Immune system, Antitumor property
Full-Text [PDF 632 kb]   (1714 Downloads)    
Type of Study: Applicable | Subject: Special
Received: 2017/09/19 | Accepted: 2019/02/28 | Published: 2019/02/28
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Besharati M, Eftekhari M. Propolis and the immune system. Journal of Biosafety. 2017; 10 (2) :131-146
URL: http://journalofbiosafety.ir/article-1-207-en.html


Volume 10, Issue 2 (8-2017) Back to browse issues page
فصل نامه علمی ایمنی زیستی Journal of Biosafety
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