Just as pathogens have evolved to colonize plants, so plants have developed means to prevent or tolerate their presence. During evolution, plants have developed mechanisms to cope with and adapt to different types of stress, including microbial infection. One of these mechanisms is to activate signaling pathways, leading to the induced expression of defense genes. Signaling transmit detection of pathogens into resistance. Such as defense mechanism, in effect activate signaling pathways can be the reinforcement of the cell wall by developing their defense structure, reactive oxygen species (ROS) production and create hypersensivity reaction (HR), programmed cell death (PCD), activation of defense genes and synthesis of secondary metabolites and defense hormones. In this article will be mentioned to review existing knowledge in conjunction with the induction of defense reaction in plants. The knowledge of these capabilities inherent in plants can be useful in the development of modern management of plant diseases.