Fungal and fungal-like diseases impose a great impact on crops annually, and fungicide-based plant protection is sometimes inevitable for efficient, economic and large-scale crop production. Regardless the long time and huge money investments to develop a new fungicide, the risk of resistance, especially to systemic fungicides, threatens the effectiency of these compounds. Today, due to the excludings of fungicides, not only from resistance, but increasingly from environmental and health concerns, the number of fungicides with different modes of action has become very restricted. Therefore, research and efforts to access fungicides with different modes of action, continuous population monitoring for fungicide resistance, finding the new resistance mechanisms and getting preventing strategies are of the most important parts for sustainable and economic fungal disease management.