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Microbial Siderophores: Structure, Production, and the Application Potential in the Pharmaceutical Industry
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Sara Javidpoor   , Ali Mohammadi , Akram Sadeghi * |
| Department of Microbial Biotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran |
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Abstract: (2513 Views) |
| Siderophores are low molecular weight organic molecules produced by microorganisms under iron-restricted conditions. These metabolites are responsible for the transport of iron into microorganisms and have a high affinity to bind to ferric iron (Fe3+) and produce iron chelates. Siderophores can be divided into three main groups: catechols, hydroxamates, and carboxylates, depending on the parts that bind to iron. Of course, siderophores that have more than one type of iron ligand group are classified into a mixed category. Siderophores are used in ecology, agriculture, bioremediation and medicine. In this article, the synthesis pathway and function of siderophores, their role as antibiotics and their use as non-antibiotic drugs have been investigated. Other applications of siderophore in various industries are also briefly mentioned. |
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| Keywords: Antibiotic, Iron chelate, Medicine, Siderophore |
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Full-Text [PDF 1690 kb]
(476 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2020/08/10 | Accepted: 2020/08/30 | Published: 2021/02/3
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